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See, that’s what the app is perfect for.

Sounds perfect Wahhhh, I don’t wanna
iwilltrytobereasonable krupkaistired
krupkaistired

the fact that if Aziraphale and Crowley did admit those feelings to each other, the only things that would change is them holding hands on the walk, Aziraphale calling Crowley “my love” instead “my dear” and Crowley occasionally hugging his boyfriend, and maybe, if they would feel like it, kiss, warms my heart

iwilltrytobereasonable

Yeah, same here. But I’m still gonna read fanfic all over the spectrum of experience, you know? Because the core of it is the love, and as long as they have that, it’s mostly in character. Everything else is degrees of …making an effort.

makes a lot of sense to me as a grey-asexual
micromultiverse biomedicool

Typhoid

biomedicool

Typhoid infection is a faecal-oral transmissible disease caused by the bacterium Salmonella enterica , serotype S typhi .

  • Humans are the only known reservoir
  • Transmission occurs through food and water contaminated by infected.
  • The current vaccines available offer only moderate protection against Salmonella typhi and almost no protection against S paratyphi , which has become a more dominant pathogen.
  • With the current vaccine efficacy and the increase in multidrug-resistant strains, cases are expected to continue to increase and become ever more challenging to treat.

Symptoms

  • Symptoms begin 6 to 30 days after exposure
  • Often there is a gradual onset of a high fever over several days.This is commonly accompanied by weakness, abdominal pain, constipation, headaches, and mild vomiting.
  • Some people develop a skin rash with rose coloured spots. In severe cases, people may experience confusion.
  • Without treatment, symptoms may last weeks or months
  • People may carry the bacterium without being affected; however, they are still able to spread the disease.
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Progression

Week one

  • Temperature rises slowly, fever fluctuations are seen with relative bradycardia (Faget sign)
  • Malaise, headache, and cough. 
  • Circulating white blood cell count drops (leukopenia) with eosinopenia and relative lymphocytosis; 

Week two

  • Patient often too tired to get up
  • High fever in plateau around 40 °C (104 °F) and bradycardia, classically with a dicrotic pulse wave (two beats per cardiac cycle). 
  • Delirium can occur
  • Rose spots appear on the lower chest and abdomen in around a third of patients. 
  • Rhonchi (rattling breathing sounds) are heard in the base of the lungs. 
  • The abdomen is distended and painful in the right lower quadrant, where a rumbling sound can be heard. 
  • Diarrhoea or constipation are common. 
  • The spleen and liver are enlarged (hepatosplenomegaly) and tender, and liver transaminases are elevated. 
  • The Widal test is strongly positive, with antiO and antiH antibodies. 

Week three

  • The fever is still very high and oscillates very little over 24 hours. -dehydration.
  • Patient is delirious (typhoid state).
  • One-third of affected individuals develop a macular rash on the trunk.
  • Platelet count goes down slowly and the risk of bleeding rises.

Complications can occur including:

  • Intestinal haemorrhage due to bleeding in congested Peyer’s patches occurs; this can be very serious, but is usually not fatal.
  • Intestinal perforation in the distal ileum - frequently fatal. It may occur without alarming symptoms until septicaemia or diffuse peritonitis sets in.
  • Respiratory diseases such as pneumonia and acute bronchitis
  • Neuropsychiatric symptoms (described as “muttering delirium” or “coma vigil”), with picking at bedclothes or imaginary objects
  • Metastatic abscesses, cholecystitis, endocarditis, and osteitis
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