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See, that’s what the app is perfect for.

Sounds perfect Wahhhh, I don’t wanna
terrypratchettappreciation silrin
silrin

Tonker and Lofty for example. It didn't matter which of them was on guard duty, the other one would be there as well. And there they were, sitting side by side on a fallen tree, staring down the slope. They were holding hands. They always held hands, when they thought they were alone. But it seemed to Polly that they didn't hold hands like people who were, well, friends. They held hands tightly, as someone who has slipped over a cliff would hold hands with a rescuer, fearing that to let go would be to fall away.

Terry Pratchett, Monstrous Regiment

GNU Terry Pratchett Discworld
doctorfoxtor vayonel-deactivated20220423
vayonel-deactivated20220423

I made a meme to remember class notes easier 🤣🤣

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Remember! Insuline acts when high glucose levels in blood increase, and uses it to create energy and eliminate that excess. Glucagon acts different! It works when glucose levels are low and increases gluconeogenesis and use of fatty acids for energy! To save glucose.

And somatostatin controls both, insuline and glucagon, to limit the effects of both hormones inhibiting, paracrinally, the secretion of these in beta and alpha cells respectively!

doctorfoxtor

A factlet that I learnt recently is that when your patient has overdosed or is suspected of having overdosed on a long acting insulin secretagogue (viz, sulphonylureas—glipizide and glibenclamide/glyburide are both popular here because they’re cheap and effective) you DON’T want to administer glucagon because glucagon actually reflexively triggers β-cells and increases insulin secretion (and so too does insulin increase glucagon secretion)! So you’ll be making it so much worse for the patient later.

Instead, infuse the somatostatin analogue octreotide! Somatostatin prevents the calcium influx into β-cells that triggers insulin release, so you’re stopping the insulin release downstream of the effect of the sulphonylurea.

terrypratchettappreciation therodentqueen
therodentqueen

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Sardines had pulled his straw hat out of his knapsack. He was holding a small walking-stick.

It was a good routine, even Maurice had to admit. Some towns had advertised for a rat piper the very first time he'd done it. People could tolerate rats in the cream, and rats in the roof, and rats in the teapot, but they drew the line at tap-dancing. If you saw tap-dancing rats, you were in big trouble. Maurice had reckoned that if only the rats could play an accordion as well they could do two towns a day.

GNU Terry Pratchett Discworld The Amazing Maurice
pictures-of-dogs thefirsthogokage

Anonymous asked:

What dogs are best at climbing?

pictures-of-dogs answered:

I assume you mean climbing trees, in which case the answer is sun dogs. They are the smallest and lightest of all dogs, and they have long, curved claws that are evolved specifically for tree-climbing. Sloth dogs, Andean dogs (spectacled dogs), American black dogs, and Asian black dogs (moon dogs) are also especially good climbers.

thefirsthogokage

Poor Ice dogs, Grizzly dogs, and Kodiak dogs.

I guess Pizzly and Grolar dogs would be extra bad at climbing trees.

pictures-of-dogs

Ice dogs are the only dogs that are truly incapable of climbing, and even then it’s only as adults! Ice dog puppies actually can climb trees. There’s a misconception that adult brown dogs (including Kodiaks and Grizzlies) can’t climb trees, but that’s not strictly true. They actually can climb trees with strong branches—not as well as smaller dogs, but definitely better than humans. I would guess that Kodiaks are generally worse climbers than Grizzlies due to their larger size.

As for Pizzlies and Grolars… I don’t think there’s any information available on their climbing abilities since they’re so rare, but yeah, I’d also guess they’re pretty bad at it.