— currentsinbiology: Scientists show how drug binds...

1.5M ratings

277k ratings

See, that’s what the app is perfect for.

Sounds perfect Wahhhh, I don’t wanna

currentsinbiology

Scientists show how drug binds with ‘hidden pocket’ on flu virus

A new study led by scientists at The Scripps Research Institute (TSRI) is the first to show exactly how the drug Arbidol stops influenza infections. The research reveals that Arbidol stops the virus from entering host cells by binding within a recessed pocket on the virus.

The researchers believe this new structural insight could guide the development of future broad-spectrum therapeutics that would be even more potent against influenza virus.

“This is a very interesting molecule, and now we know where it binds and precisely how it works,” said study senior author Ian Wilson, Hanson Professor of Structural Biology, chair of the Department of Integrative Structural and Computational Biology and member of the Skaggs Institute for Chemical Biology at TSRI.

The study was published in the journal Proceedings of the National Academy of Sciences.

Rameshwar U. Kadam, Ian A. Wilson. Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol. Proceedings of the National Academy of Sciences, 2016; 201617020 DOI: 10.1073/pnas.1617020114

This is a 3-dimensional illustration showing the different features of an influenza virus, including the surface proteins hemagglutinin (HA) and neuraminidase (NA)/CDC

More you might like

romanceyourdemons

ladyshinga

mariacallous

#'accidentally'

bisexualshakespeare

[ID: Tweet from Leah @grammedevanille reads “RIP Aux Anglophones Parce Que Le Jeu De Mots Avec Ken Est Incroyaaaaable
Quote Reply by @MathildeMerouani reads: French twitter losing its mind because they translated the Barbie poster literally and accidentally made a pun that reads 'She knows how to do everything. he just knows how to f*ck.'

Attached is a Barbie poster showing Barbie sitting on Ken's left shoulder and grinning. She has one hand splayed over his face. Text reads: Margot Robbie, Ryan Gosling. Elle peut tout faire. Lui, c'est juste Ken. Au cinéma le 19 Juillet. /End]

squeeegs

mareepkeeper

New patch just dropped

an image of a black patch with painted details. on the top right is a stylized rendition of Disco Elysium character "The Insulindian Phasmid". to the left and below this character portrait is a pale fog. inside the fog in pink letters reads "you are a violent and irrepressible miracle".

buttercupyarnart

forever70s

70s crochet

mousearmymittenco

I think that the legipillar outfit for babies is a fine idea, but that baby is developmentally way past the legipillar stage and is going to fall over. The baby is going to faceplant. Kid is like 3 years old. Dude. That kid is thinking about getting into a good college. That potato bag design is gonna hold him back

mousearmymittenco

Good take; this is a situation I did not account for, and I reckon that compared to a toddler, most adults are less likely to forget/ignore that their legs are in a sleeping bag and try to take off running.